Hyperalgesia refers to an increased sensitivity to pain. It can occur during alcohol withdrawal, and may contribute to a relapse to drinking. Alternative therapies such as acupuncture and electroacupuncture (EA; which combines acupuncture with electrical stimulation) are effective in reducing pain and, possibly, alcohol-withdrawal symptoms. This rodent study investigated whether EA can alleviate hyperalgesia during alcohol withdrawal, potentially reducing the risk of a relapse to drinking, and whether it achieves this effect via action at mu opioid receptors (MORs) located in a brain region called the lateral habenula.
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